Sfiso was born in Clermont, on the periphery of Durban in KwaZulu Natal on 3 May 1963. He says that he remembers drawing in the sand and modeling cattle from clay as a young boy and drawing geography maps for his friends at school because he was good at it. He attended the Abangani Open School in Durban in 1982 and in 1983 he joined the Little Abbey Theatre where he received formal art tuition for the first time. In 1986, the young artist was employed as a student teacher in screen printing at the Community Arts Workshop, located in the old station buildings in Durban.
In 1989 his career as an artist was bolstered by his participation in the Thupelo Workshops initiated by David Koloane and Bill Ainslie in Johannesburg. His profession was further enhanced in 1988 when the South African National Gallery in Cape Town purchased his ‘Letters to God’ drawing series for their permanent collection. Shortly thereafter the Tatham Art Gallery in Pietermaritzburg purchased the series Letters for my Child. During the 1980’s Ka-Mkame embarked on a new series illustrating the trials and tribulations of women, particularly African women. He openly acknowledges that his compassion and empathy for women stems from the love and admiration he had for his mother.